Cat. No. 5986
Chemical Name: 3-(4-Chlorophenyl)-5-(4-nitrophenyl
Biological ActivitySelective ARF6 inhibitor (IC50 = 1.0 μM). Selective for ARF6 over other ARF family members and small GTPases. Inhibits ARF6 activation in uveal melanoma cells in vitro and blocks downstream signaling pathways of oncogenic GNAQ. Reduces tumorigenesis in mouse model of uveal melanoma.
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Certificate of Analysis / Product Datasheet / Safety Datasheet
Yoo et al (2016) ARF6 is an actionable node that orchestrates oncogenic GNAQ signaling in uveal melanoma. Cancer Cell. 29 889. PMID: 27265506.
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Keywords: NAV 2729, supplier, NAV2729, small, G, proteins, Gαq, GTPases, inhibitors, inhibits, selective, ARF6, GNAQ, Tocris Bioscience, GTPase Inhibitor products