Cat. No. 5983
Chemical Name: 3,4,5,6,7,9-Hexahydro-3,3,6,6-tetra
Biological ActivityPotent δ-opioid receptor positive allosteric modulator (EC50 = 30 nM). Exhibits 100-fold selectivity for δ over μ-opioid receptor. Enhances affinity of [Leu5]-Enkephalin (Cat.No. 1889), SNC 80 (Cat.No. 0764) and TAN67 for the δ-opioid receptor.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Shang et al (2016) Proposed mode of binding and action of positive allosteric modulators at opioid receptors. ACS Chem.Biol. 11 1220. PMID: 26841170.
Burford et al (2015) Discovery, synthesis, and molecular pharmacology of selective positive allosteric modulators of the δ-opioid receptor. J.Med.Chem. 58 4220. PMID: 25901762.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses BMS 986187 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: BMS 986187, supplier, BMS986187, potent, delta-opioid, receptors, d-opioid, δ-opioid, positive, allosteric, modulators, PAMs, Tocris Bioscience, δ Opioid Receptor Modulator products