Cat. No. 5983
Chemical Name: 3,4,5,6,7,9-Hexahydro-3,3,6,6-tetra
Biological ActivityPotent δ-opioid receptor positive allosteric modulator (EC50 = 30 nM). Exhibits 100-fold selectivity for δ over μ-opioid receptor. Enhances affinity of [Leu5]-Enkephalin (Cat.No. 1889), SNC 80 (Cat.No. 0764) and TAN 67 (Cat.No. 0921) for the δ-opioid receptor.
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Certificate of Analysis / Product Datasheet / Safety Datasheet
Shang et al (2016) Proposed mode of binding and action of positive allosteric modulators at opioid receptors. ACS Chem.Biol. 11 1220. PMID: 26841170.
Burford et al (2015) Discovery, synthesis, and molecular pharmacology of selective positive allosteric modulators of the δ-opioid receptor. J.Med.Chem. 58 4220. PMID: 25901762.
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Keywords: BMS 986187, supplier, BMS986187, potent, delta-opioid, receptors, d-opioid, δ-opioid, positive, allosteric, modulators, PAMs, Tocris Bioscience, δ Opioid Receptor Modulator products
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