Cat. No. 5983
Chemical Name: 3,4,5,6,7,9-Hexahydro-3,3,6,6-tetra
Biological ActivityPotent δ-opioid receptor positive allosteric modulator (EC50 = 30 nM). Exhibits 100-fold selectivity for δ over μ-opioid receptor. Enhances affinity of [Leu5]-Enkephalin (Cat.No. 1889), SNC 80 (Cat.No. 0764) and TAN 67 (Cat.No. 0921) for the δ-opioid receptor.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Shang et al (2016) Proposed mode of binding and action of positive allosteric modulators at opioid receptors. ACS Chem.Biol. 11 1220. PMID: 26841170.
Burford et al (2015) Discovery, synthesis, and molecular pharmacology of selective positive allosteric modulators of the δ-opioid receptor. J.Med.Chem. 58 4220. PMID: 25901762.
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Keywords: BMS 986187, supplier, BMS986187, potent, delta-opioid, receptors, d-opioid, δ-opioid, positive, allosteric, modulators, PAMs, Tocris Bioscience, δ Opioid Receptor Modulator products
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