Cat. No. 5979
Chemical Name: (5Z,8Z,11Z,14Z,17Z)-5,8,11,14,17-Ei
Biological ActivityEndogenous polyunsaturated fatty acid. Stimulates ERK1/2 and C/EBPβ phosphorylation, and induces demethylation of CpG island B in U937 leukemia cells. Attenuates proliferation of U9137 cells, and induces cell cycle arrest and apoptosis in pancreatic cells in vitro. Also inhibits leukotriene B4 synthesis in rats.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Ceccarelli et al (2014) Eicosapentaenoic acid activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. PLoS One 9 e85025. PMID: 24454781 .
Lai et al (1996) Cell cycle arrest and induction of apoptosis in pancreatic cancer cells exposed to eicosapentaenoic acid in vitro. Br.J.Cancer 74 1375. PMID: 8912532 .
James et al (1993) Effect of dietary supplementation with n-9 eicosatrienoic acid on leukotriene B4 synthesis in rats: a novel approach to inhibition of eicosanoid synthesis. J.Exp.Med. 178 2261. PMID: 8245797.
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Keywords: Eicosapentaenoic Acid, supplier, endogenous, polyunsaturated, fatty, acids, stimulates, ERK, phosphorylation, leukotriene-B4, synthesis, inhibits, Tocris Bioscience, ERK products
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