Ro 3280

Cat. No. 5968new

Ro 3280 C27H35F2N7O3 [1062243-51-9]

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Chemical Name: 4-[(9-Cyclopentyl-7,7-difluoro-6,7,8,9-tetrahydro-5-methyl-6-oxo-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide

Biological Activity

Potent and selective PLK inhibitor (IC50 = 3 nM). Exhibits selectivity for PLK1 over a panel of other kinases. Inhibits growth of a range of tumor cells lines in vitro and induces apoptosis in leukemia cells. Exhibits antitumor activity in mouse colorectal and nasopharyngeal cancer models in vivo.

Technical Data

M.Wt:
543.61
Formula:
C27H35F2N7O3
Solubility:
Soluble to 50 mM in DMSO and to 50 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
1062243-51-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Wang et al (2015) Molecular targeting of the oncoprotein PLK1 in pediatric acute myeloid leukemia: RO3280, a novel PLK1 inhibitor, induces apoptosis in leukemia cells. Int.J.Mol.Sci. 16 1266. PMID: 25574601.

Cheung et al (2013) Polo-like kinase inhibitor Ro5203280 has potent antitumor activity in nasopharyngeal carcinoma. Mol.Cancer Ther. 12 1393. PMID: 23686835.

Chen et al (2012) Identification of novel, potent and selective inhibitors of Polo-like kinase 1. Bioorg.Med.Chem.Lett. 22 1247. PMID: 22172702.

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Citations are publications that use Tocris products.

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Keywords: Ro 3280, supplier, Ro3280, Polo-like, kinases, inhibitors, inhibits, apoptosis, inducers, anticancer, PLK1, potent, selective, Tocris Bioscience, Polo-like Kinase Inhibitor products

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