ML 233

Cat. No. 5966new

ML 233 C19H21NO4S

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Chemical Name: (E)-4-Methyl-5-(((phenylsulfonyl)oxy)imino)-[1,1'-bi(cyclohexane)]-3,6-dien-2-one

Biological Activity

Non-peptide apelin receptor agonist (EC50 = 3.7 μM); exhibits >21-fold selectivity over the closely related angiotensin 1 receptor (EC50 = >79 μM).

Technical Data

M.Wt:
359.44
Formula:
C19H21NO4S
Solubility:
Soluble to 50 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Yang et al (2015) Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system. Trends Pharmacol Sci. 36 560. PMID: 26143239.

Khan et al (2011) Functional agonists of the apelin (APJ) receptor. Probe Reports from the NIH Molecular Libraries Program. PMID: 22834038.

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Keywords: ML 233, supplier, ML233, Potent, non, peptide, agonists, APJ, Receptors, Apelin, adipokines, Tocris Bioscience, Apelin Receptor Agonist products

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