3-AP

Cat. No. 5962new

3-AP C7H9N5S [143621-35-6]

Price and Availability

For 3-AP pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: 3-aminopyridine-2-carboxaldehyde thiosemicarbazone

Chemical Name: 2-[(3-Amino-2-pyridinyl)methylene]hydrazinecarbothioamide

Biological Activity

Ribonucleotide reductase inhibitor. Also an iron chelator. Inhibits leukemia cell growth and acts in synergy with cisplatin (Cat. No.2251). Active in vivo.

Technical Data

M.Wt:
195.24
Formula:
C7H9N5S
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
143621-35-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Arid et al (2015) Nucleotide metabolism, oncogene-induced senescence and cancer. Cancer Letters 356 204. PMID: 24486217.

Finch et al (1999) Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone; 3-AP): an inhibitor of ribonucleotide reductase with antineoplastic activity. Adv.Enzyme Regul. 39 3. PMID: 10470363.

Liu et al (1992) Synthesis and antitumor activity of amino derivatives of pyridine-2-carboxaldehyde thiosemicarbazone. J.Med.Chem. 35 3672. PMID: 1433178.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for 3-AP include:

Chitambar et al (2013) Iron-targeting antitumor activity of gallium compounds and novel insights into triapine(®)-metal complexes. Antioxid.Redox Signal. 18 956. PMID: 22900955.

Do you know of a great paper that uses 3-AP from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: 3-AP, supplier, Ribonucleotide, reductase, inhibitors, inhibits, chelator, leukemia, cisplatin, active, in, vivo, Tocris Bioscience, Ribonucleotide Reductase Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

New Product Guide

New Product Guide (Fall/Winter 2016)

Our New Product guide highlights over 100 new products added in the second half of 2016. Request copy or view PDF today.

divider line

Bio-Techne Events

One Day Symposium

Bio-Techne Symposium 2017

Epigenetic Regulation of Stem Cell Differentiation

March 1, 2017

Amsterdam, The Netherlands