Cat. No. 5962

3-AP C7H9N5S [143621-35-6]

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Alternative Name: 3-aminopyridine-2-carboxaldehyde thiosemicarbazone

Chemical Name: 2-[(3-Amino-2-pyridinyl)methylene]hydrazinecarbothioamide

Biological Activity

Ribonucleotide reductase inhibitor. Also an iron chelator. Inhibits leukemia cell growth and acts in synergy with cisplatin (Cat. No.2251). Active in vivo.

Technical Data

Soluble to 100 mM in DMSO
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Arid et al (2015) Nucleotide metabolism, oncogene-induced senescence and cancer. Cancer Letters 356 204. PMID: 24486217.

Finch et al (1999) Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone; 3-AP): an inhibitor of ribonucleotide reductase with antineoplastic activity. Adv.Enzyme Regul. 39 3. PMID: 10470363.

Liu et al (1992) Synthesis and antitumor activity of amino derivatives of pyridine-2-carboxaldehyde thiosemicarbazone. J.Med.Chem. 35 3672. PMID: 1433178.

If you know of a relevant reference for 3-AP please let us know.

Citations are publications that use Tocris products. Selected citations for 3-AP include:

Chitambar et al (2013) Iron-targeting antitumor activity of gallium compounds and novel insights into triapine(®)-metal complexes. Antioxid.Redox Signal. 18 956. PMID: 22900955.

Do you know of a great paper that uses 3-AP from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: 3-AP, supplier, Ribonucleotide, reductase, inhibitors, inhibits, chelator, leukemia, cisplatin, active, in, vivo, Tocris Bioscience, Ribonucleotide Reductase Inhibitor products

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