Cat. No. 5962
Alternative Name: 3-aminopyridine-2-carboxaldehyde thiosemicarbazone
Chemical Name: 2-[(3-Amino-2-pyridinyl)methylene]h
Biological ActivityRibonucleotide reductase inhibitor. Also an iron chelator. Inhibits leukemia cell growth and acts in synergy with cisplatin (Cat. No.2251). Active in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Arid et al (2015) Nucleotide metabolism, oncogene-induced senescence and cancer. Cancer Letters 356 204. PMID: 24486217.
Finch et al (1999) Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone; 3-AP): an inhibitor of ribonucleotide reductase with antineoplastic activity. Adv.Enzyme Regul. 39 3. PMID: 10470363.
Liu et al (1992) Synthesis and antitumor activity of amino derivatives of pyridine-2-carboxaldehyde thiosemicarbazone. J.Med.Chem. 35 3672. PMID: 1433178.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for 3-AP include:
Chitambar et al (2013) Iron-targeting antitumor activity of gallium compounds and novel insights into triapine(®)-metal complexes. Antioxid.Redox Signal. 18 956. PMID: 22900955.
Do you know of a great paper that uses 3-AP from Tocris? If so please let us know.
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Keywords: 3-AP, supplier, Ribonucleotide, reductase, inhibitors, inhibits, chelator, leukemia, cisplatin, active, in, vivo, Tocris Bioscience, Ribonucleotide Reductase Inhibitor products
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