Cat. No. 5961
Chemical Name: N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl
Biological ActivitySelective TrkB receptor agonist. Protects neurons from excitotoxicity. Protects retinas from light-induced retinal degeneration (LIRD) in vivo. Blood brain barrier and blood-retinal barrier penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Setterholm et al (2015) Gram-scale, chemoselective synthesis of N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-oxopiperidine-3-carboxamide (HIOC) Tetrahedron Lett. 56 3413. PMID: 26028783.
Shen et al (2012) N-acetyl serotonin derivatives as potent neuroprotectants for retinas Proc.Natl.Acad.Sci.USA 109 3540. PMID: 22331903.
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Keywords: HIOC, supplier, Selective, TrkB, receptor, agonists, agonism, excitotoxicity, retinal, degeneration, blood, brain, barrier, BBB, neuroprotectant, Tocris Bioscience, Trk Receptor Agonist products
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