Cat. No. 5961
Chemical Name: N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl
Biological ActivitySelective TrkB receptor agonist. Protects neurons from excitotoxicity. Protects retinas from light-induced retinal degeneration (LIRD) in vivo. Blood brain barrier and blood-retinal barrier penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Setterholm et al (2015) Gram-scale, chemoselective synthesis of N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-oxopiperidine-3-carboxamide (HIOC) Tetrahedron Lett. 56 3413. PMID: 26028783.
Shen et al (2012) N-acetyl serotonin derivatives as potent neuroprotectants for retinas Proc.Natl.Acad.Sci.USA 109 3540. PMID: 22331903.
If you know of a relevant reference for HIOC please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses HIOC from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: HIOC, supplier, Selective, TrkB, receptor, agonists, agonism, excitotoxicity, retinal, degeneration, blood, brain, barrier, BBB, neuroprotectant, Tocris Bioscience, Trk Receptor Agonist products
Find multiple products by catalog number
New Products in this Area
Potent and selective PDGFR inhibitorGSK 1363089
Potent inhibitor of MET, VEGFR2, Ron and AXLPF 06273340
Potent and selective pan-Trk inhibitor; peripherally restricted
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.