Autocamtide-2-related inhibitory peptide, myristoylated

Cat. No. 5959

Autocamtide-2-related inhibitory peptide, myristoylated Myr-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu

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Alternative Names: Myr-AIP, AIP Myristoylated

Biological Activity

CaM kinase II inhibitor; enhanced cell permeable derivative of Autocamtide-2-related inhibitory peptide (Cat No. 1688). Pretreatment blocks reinstatement of morphine-seeking behavior in vivo.

Technical Data

M.Wt:
1708.12
Formula:
C78H142N22O20
Sequence:
KKALRRQEAVDAL

(Modifications: Lys-1 = Myr-Lys)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Store at -20°C
CAS No:
201422-04-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Liu et al (2012) Inhibition of CaMKII activity in the nucleus accumbens shell blocks the reinstatement of morphine-seeking behavior in rats. Neurosci.Lett. 518 167. PMID: 22579819.

Laabich et al (2000) Neuroprotective effect of AIP on N-methyl-D-aspartate-induced cell death in retinal neurons. Brain Res.Mol.Brain Res. 85 32. PMID: 11146104.

Ishida et al (1995) A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II. Biochem.Biophys.Res.Commun. 212 806. PMID: 7626114.

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Keywords: Autocamtide-2-related inhibitory peptide, myristoylated, supplier, Calmodulin-dependent, protein, kinases, CaM, kinase-II, inhibitors, inhibits, addiction, cell, permeable, Tocris Bioscience, Calmodulin-Dependent Kinase Inhibitor products

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