Cat. No. 5953
Chemical Name: 7-[(4-Chlorophenyl)[(3-hydroxy-2-py
Biological ActivityHIF-prolyl hydroxylase-2 (PHD2) inhibitor. Blocks glutamate induced ROS production in HT-22 cells, independent of MnSOD. Exhibits neuroprotective effects and enhances functional recovery in rodent intracerebral hemorrhage models, via inhibition of ATF4 dependent genes. Brain penetrant. Also antioxidant.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Karuppagounder et al (2016) Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models. Sci.Transl.Med. 8 328ra29. PMID: 26936506.
Neitemeier et al (2016) Inhibition of HIF-prolyl-4-hydroxylases prevents mitochondrial impairment and cell death in a model of neuronal oxytosis. Cell Death Dis. 7 e2214. PMID: 27148687.
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Keywords: Adaptaquin, supplier, HIF-PHD, inhibitors, hypoxia, inducible, factor, prolyl, hydroxylases, inhibits, antioxidant, neuroprotective, brain, penetrant., Tocris Bioscience, Hydroxylase Inhibitor products
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