Cat. No. 5953
Chemical Name: 7-[(4-Chlorophenyl)[(3-hydroxy-2-py
Biological ActivityHIF-prolyl hydroxylase-2 (PHD2) inhibitor. Blocks glutamate induced ROS production in HT-22 cells, independent of MnSOD. Exhibits neuroprotective effects and enhances functional recovery in rodent intracerebral hemorrhage models, via inhibition of ATF4 dependent genes. Brain penetrant. Also antioxidant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Karuppagounder et al (2016) Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models. Sci.Transl.Med. 8 328ra29. PMID: 26936506.
Neitemeier et al (2016) Inhibition of HIF-prolyl-4-hydroxylases prevents mitochondrial impairment and cell death in a model of neuronal oxytosis. Cell Death Dis. 7 e2214. PMID: 27148687.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Adaptaquin from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Adaptaquin, supplier, HIF-PHD, inhibitors, hypoxia, inducible, factor, prolyl, hydroxylases, inhibits, antioxidant, neuroprotective, brain, penetrant., Tocris Bioscience, Hydroxylase Inhibitor products
Find multiple products by catalog number
New Products in this Area
CYP17 inhibitor; also androgen receptor antagonistPF 04449613
Potent PDE9 inhibitor; brain penetrantEggmanone
Potent and selective PDE4 inhibitor; suppresses hedgehog signaling
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.