WAY 252623

Cat. No. 5951

WAY 252623 C21H12ClF5N2 [875787-07-8]

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Chemical Name: 2-[(2-Chloro-4-fluorophenyl)methyl]-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole

Biological Activity

Potent LXR agonist (IC50 values are 24 and 179 nM for LXRβ and LXRα, respectively). Reduces total serum cholesterol and LDL cholesterol, and inhibits lesion growth in models of atherosclerosis. Increases ABCA1 and ABCG1 mRNA levels in rat peripheral blood cells. Orally bioavailable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M.Wt:
422.78
Formula:
C21H12ClF5N2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
875787-07-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Quinet et al (2009) LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse. J.Lipid Res. 50 2358. PMID: 19318684.

DiBlasio-Smith et al (2008) Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells. J.Transl.Med. 6. PMID: 18925943.

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Keywords: WAY 252623, supplier, LXR, liver, X, receptor, alpha, beta, LXRa, LXRb, β, α, potent, agonists, agonism, orally, bioavailable, Tocris Bioscience, LXR-like Receptor Agonist products

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