Cat. No. 5951
Chemical Name: 2-[(2-Chloro-4-fluorophenyl)methyl]
Biological ActivityPotent LXR agonist (IC50 values are 24 and 179 nM for LXRβ and LXRα, respectively). Reduces total serum cholesterol and LDL cholesterol, and inhibits lesion growth in models of atherosclerosis. Increases ABCA1 and ABCG1 mRNA levels in rat peripheral blood cells. Orally bioavailable.
Licensing InformationSold for research purposes under agreement from Pfizer Inc.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Quinet et al (2009) LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse. J.Lipid Res. 50 2358. PMID: 19318684.
DiBlasio-Smith et al (2008) Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells. J.Transl.Med. 6. PMID: 18925943.
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Keywords: WAY 252623, supplier, LXR, liver, X, receptor, alpha, beta, LXRa, LXRb, β, α, potent, agonists, agonism, orally, bioavailable, Tocris Bioscience, LXR-like Receptor Agonist products
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