2',3'-cGAMP sodium salt

Cat. No. 5945

2',3'-cGAMP sodium salt C20H22N10Na2O13P2

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Chemical Name: 2',3'-Cyclic guanosine monophosphate-adenosine monophosphate sodium salt

Biological Activity

Endogenous high affinity STING agonist (Kd values are 3.79 and 120 nM for human and rat STING, respectively). Induces repolarization of M2 macrophages in vitro.

Technical Data

M.Wt:
718.37
Formula:
C20H22N10Na2O13P2
Solubility:
Soluble to 50 mM in water
Purity:
>98 %
Storage:
Store at -20°C

Resources

Other Information

  • This product is sold in units of 359μg, equivalent to 0.5μmol.

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Zhang et al (2015) Rat and human STINGs profile similarly towards anticancer/antiviral compounds. Sci.Rep. 5 18035. PMID: 26669264.

Downey et al (2014) DMXAA causes tumor site-specific vascular disruption in murine non-small cell lung cancer, and like the endogenous non-canonical cyclic dinucleotide STING agonist, 2'3'-cGAMP, induces M2 macrophage repolarization. PLoS One 9 e99988. PMID: 24940883.

Zhang et al (2013) Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol.Cell. 51 226. PMID: 23747010.

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Citations are publications that use Tocris products.

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Keywords: 2',3'-cGAMP sodium salt, supplier, endogenous, high, affinity, STING, agonists, Tocris Bioscience, STING-Dependent Signaling Agonist products

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