Cat. No. 5943
Chemical Name: N-[(1R,3S,5S)-9-(2-((2-Chlorophenyl
Biological ActivityPotent and selective hCXCR6 antagonist (IC50 = 140 nM); 100-fold less active at the murine CXCR6 receptor (IC50 = 18 μM). Exhibits selectivity over CXCR5, CXCR4, CCR6 and APJ receptors (IC50 >79 μM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Hershberger et al (2012) Probing the CXCR6/CXCL16 Axis: targeting prevention of prostate cancer metastasis. Probe Reports from the NIH Molecular Libraries Program. PMID: 24049849.
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Keywords: ML 339, supplier, ML339, Potent, human, CXCR6, antagonists, antagonism, metastasis, Tocris Bioscience, Chemokine CXC Receptor Antagonist products