PF 6274484

Cat. No. 5939new

PF 6274484 C18H14ClFN4O2 [1035638-91-5]

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Chemical Name: N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-2-propenamide

Biological Activity

High affinity and potent covalent EGFR kinase inhibitor (Ki = 0.14 nM). Inhibits autophosphorylation of WT and mutant EGFR in tumor cells (IC50 values are 5.8 and 6.6 nM, respectively).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

Soluble to 100 mM in DMSO
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Schwartz et al (2014) Covalent EGFR inhibitor analysis reveals importance of reversible interactions to potency and mechanisms of drug resistance. Proc.Natl.Acad.Sci.U.S.A. 111 173. PMID: 24347635.

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Keywords: PF 6274484, supplier, PF6274484, epidermal, growth, factor, receptors, EGFR, kinase, inhibitors, inhibits, potent, high, affinity, covalent, Tocris Bioscience, EGFR Inhibitor products

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