A 779

Cat. No. 5937

A 779 Asp-Arg-Val-Tyr-Ile-His-D-Ala

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Biological Activity

Selective Mas receptor (Ang-(1-7) receptor) antagonist. Exhibits no significant affinity for AT1 or AT2 receptors at a concentration of 1 μM. Inhibits antidiuretic effect of Ang-(1-7) in water-loaded rats. Also attenuates Monocrotaline-induced pulmonary fibrosis in rats.

Technical Data

M.Wt:
872.98
Formula:
C39H60N12O11
Sequence:
DRVYIHA

(Modifications: Ala-7 = D-Ala)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Store at -20°C
CAS No:
159432-28-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Bruce et al (2015) Selective activation of angiotensin AT2 receptors attenuates progression of pulmonary hypertension and inhibits cardiopulmonary fibrosis. Br.J.Pharmacol. 172 2219. PMID: 25522140.

Becker et al (2005) Cardiovascular effects of angiotensin II and angiotensin-(1-7) at the RVLM of trained normotensive rats. Brain Res. 1040 121. PMID: 15804433.

Santos et al (1994) Characterization of a new angiotensin antagonist selective for angiotensin-(1-7): evidence that the actions of angiotensin-(1-7) are mediated by specific angiotensin receptors. Brain Res.Bull. 35 293. PMID: 7850477.

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Keywords: A 779, supplier, A779, selective, mas, receptors, antagonists, angiotensin, ang-(1-7), Tocris Bioscience, Other Angiotensin Receptor Antagonist products

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