NCT 501 hydrochloride
Cat. No. 5934
Chemical Name: 8-[[4-(Cyclopropylcarbonyl)-1-piper
Biological ActivityPotent and selective ALDH1A1 inhibitor (IC50 = 40 nM). Exhibits >1000-fold selectivity for ALDH1A1 over ALDH3A1, ALDH1B1, ALDH2, HPGD and HSD17β4. Also selective over a panel of 168 GPCRs. Blood-brain barrier permeable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Yang et al (2015) Discovery of NCT-501, a potent and selective theophylline-based inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1). J.Med.Chem. 58 5967. PMID: 26207746.
If you know of a relevant reference for NCT 501 hydrochloride please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses NCT 501 hydrochloride from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: NCT 501 hydrochloride, supplier, NCT501, hydrochloride, potent, selective, ALDH1A1, inhibitors, inhibits, cancer, stem, cells, obesity, inflammation, antitumor, 1802088-50-1, Tocris Bioscience, Aldehyde Dehydrogenase Inhibitor products
Find multiple products by catalog number
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.