Cat. No. 5931
Chemical Name: 4-[2-(3-Amino-1H-pyrazol-4-yl)-4-ch
Biological ActivityPotent and selective Nav1.7 channel blocker (IC50 = 8, 11 and 171 nM for mouse, human and rat Nav1.7, respectively). Exhibits selectivity for Nav1.7 over other Nav1 channels (IC50 values are 0.11, 0.16, 0.85, 10, 11 and 25 μM for Nav1.2, Nav1.6, Nav1.1, Nav1.4, Nav1.3 and Nav1.5, respectively). Also exhibits selectivity over a panel of 81 other ion channels, receptors, enzymes and transporters. Blocks spontaneous firing of inherited erythromelalgia (IEM)-derived iPSC sensory neurons in vitro.
Licensing InformationSold for research purposes under agreement from Pfizer Inc.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Alexandrou et al (2016) Subtype-selective small molecule inhibitors reveal a fundamental role for Nav1.7 in nociceptor electrogenesis, axonal conduction and presynaptic release. PLoS One 11 e0152405. PMID: 27050761.
Cao et al (2016) Pharmacological reversal of a pain phenotype in iPSC-derived sensory neurons and patients with inherited erythromelalgia. Sci.Transl.Med. 8 335ra56. PMID: 27099175.
If you know of a relevant reference for PF 05089771 please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses PF 05089771 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: PF 05089771, supplier, PF05089771, potent, selective, Nav1.7, sodium, channels, neuropathic, pain, Tocris Bioscience, Voltage-gated Sodium (NaV) Channel Blocker products
Find multiple products by catalog number
New Products in this Area
Potent and selective Nav1.6 channel blocker
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.