Cat. No. 5930
Chemical Name: 2-(4-Methylphenyl)-1,2-benzisothiaz
Biological ActivityJARID1 (Jumonji AT-Rich Interactive Domain 1) inhibitor (IC50 values are 3, 4.9 and 6 μM for JARID1B, 1A and 1C, respectively). Selective for JARID1 over UTX and JMJD3. Increases levels of methylated H3K4 in JARIDB1-transfected HeLa cells and MCF7 cells. Inhibits proliferation of breast cancer cell lines expressing high levels of JARIDB1.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Sayegh et al (2013) Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen. J.Biol.Chem. 288 9408. PMID: 23408432.
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Keywords: PBIT, supplier, Jumonji, AT-Rich, Interactive, Domain, 1, JARID1B, histone, lysine, demethylase, inhibitors, inhibits, breast, cancer, Tocris Bioscience, Histone Demethylase Inhibitor products
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