BeKm 1

Cat. No. 5929

BeKm 1 Arg-Pro-Thr-Asp-Ile-Lys-Cys-Ser-Glu-Ser-Tyr-Gln-Cys-Phe-Pro-Val-Cys-Lys-Ser-Arg-Phe-Gly-Lys-Thr-Asn-Gly-Arg-Cys-Val-Asn-Gly-Phe-Cys-Asp-Cys-Phe

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Biological Activity

Potent and selective KV11.1 (hERG) channel blocker. Selective for KV11.1 over a panel of 14 other potassium channels. Dose-dependently prolongs QTc interval in isolated rabbit heart.

Technical Data


(Modifications: Disulfide bridge: 7-28,13-33,17-35)

Soluble to 1 mg/ml in water
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Qu et al (2011) BeKm-1, a peptide inhibitor of human ether-a-go-go-related gene potassium currents, prolongs QTc intervals in isolated rabbit heart. J.Pharmacol.Exp.Ther. 337 2. PMID: 21205913.

Korolkova et al (2002) New binding site on common molecular scaffold provides HERG channel specificity of scorpion toxin BeKm-1. J.Biol.Chem. 277 43104. PMID: 12151390.

Korolkova et al (2001) An ERG channel inhibitor from the scorpion Buthus eupeus. J.Biol.Chem. 276 9868. PMID: 11136720.

If you know of a relevant reference for BeKm 1 please let us know.

Citations are publications that use Tocris products.

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View Related Products by Product Action

Keywords: BeKm 1, supplier, BeKm1, human, ether-a-go-go, hERG, voltage-gated, potassium, channel, blockers, blocks, K+, Kv11.1, venoms, Tocris Bioscience, Voltage-gated Potassium (KV) Channel Blocker products

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