Cat. No. 5919
Chemical Name: 6-[[4-(Cyclopropylmethyl)-1-piperaz
Biological ActivityPotent and selective PI 3-kinase p110δ inhibitor (IC50 = 5 nM; Ki = 1.5 nM). Exhibits >100-fold selectivity over p100α, p100γ and p100β isoforms (IC50 values are 600, 910, >10,000 nM, respectively). Attenuates 4TI tumor growth and metastasis in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Ali et al (2014) Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer. Nature 510 407. PMID: 24919154.
Porta et al (2014) Targeting PI3K/Akt/mTOR signaling in cancer. Front.Oncol. 4 64. PMID: 24782981.
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Keywords: PI 3065, supplier, PI, 3-kinase, PI3K, phosphoinositide, 3-kinases, inhibitors, inhibits, potent, selective, p110d, delta, δ, Tocris Bioscience, PI 3-kinase Inhibitor products
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