TPPU

Cat. No. 5918

TPPU C16H20F3N3O3 [1222780-33-7]

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Chemical Name: N-[1-(1-Oxopropyl)-4-piperidinyl]-N'-[4-(trifluoromethoxy)phenyl]urea

Biological Activity

Potent soluble epoxide hydrolase (sEH) inhibitor (IC50 values are 1.1 and 2.1 nM for murine and human receptor, respectively). Inhibits MAPK and NF-κB signaling, as well as reducing ER stress and cell death in models of pancreatitis. Exhibits antidepressant effects in a social defeat stress model. Orally bioavailable and brain penetrant.

Technical Data

M.Wt:
359.34
Formula:
C16H20F3N3O3
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
1222780-33-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Ren et al (2016) Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress. Proc.Natl.Acad.Sci.U.S.A. 113 E1944. PMID: 26976569.

Bettaieb et al (2015) Soluble epoxide hydrolase pharmacological inhibition ameliorates experimental acute pancreatitis in mice. Mol.Pharmacol. 88 281. PMID: 25993999.

Rose et al (2010) 1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain. J.Med.Chem. 53 7067. PMID: 20812725.

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Citations are publications that use Tocris products.

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Keywords: TPPU, supplier, potent, soluble, epoxide, hydrolase, inhibitors, inhibits, brain, penetrant, orally, bioavailable, antidepressant, anti-inflammatory, Tocris Bioscience, Other Hydrolase Inhibitor products

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