Cat. No. 5918
Chemical Name: N-[1-(1-Oxopropyl)-4-piperidinyl]-N
Biological ActivityPotent soluble epoxide hydrolase (sEH) inhibitor (IC50 values are 1.1 and 2.1 nM for murine and human receptor, respectively). Inhibits MAPK and NF-κB signaling, as well as reducing ER stress and cell death in models of pancreatitis. Exhibits antidepressant effects in a social defeat stress model. Orally bioavailable and brain penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Ren et al (2016) Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress. Proc.Natl.Acad.Sci.U.S.A. 113 E1944. PMID: 26976569.
Bettaieb et al (2015) Soluble epoxide hydrolase pharmacological inhibition ameliorates experimental acute pancreatitis in mice. Mol.Pharmacol. 88 281. PMID: 25993999.
Rose et al (2010) 1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain. J.Med.Chem. 53 7067. PMID: 20812725.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses TPPU from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: TPPU, supplier, potent, soluble, epoxide, hydrolase, inhibitors, inhibits, brain, penetrant, orally, bioavailable, antidepressant, anti-inflammatory, Tocris Bioscience, Other Hydrolase Inhibitor products
Find multiple products by catalog number
New Products in this Area
Potent and selective poly (ADP ribose) glycohydrolase (PARG) inhibitor; cell permeableJZP 361
Potent and selective reversible MAGL inhibitorURB 602
Non-competitive MAGL inhibitor(S)-Crizotinib
MTH1 inhibitorJZP 430
Potent and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor
One Day Symposium
March 1, 2017
Amsterdam, The Netherlands