Cat. No. 5917
Chemical Name: N-[3',4'-Dichloro(1,1'-biphenyl)-yl]-4
Biological ActivityPotent microsomal prostaglandin E synthase 1 (mPGES-1) inhibitor (IC50 values are 16.5 and 1080 nM for human and rat mPGES-1, respectively). Exhibits >6500-fold selectivity for mPGES-1 over COX-1 and COX-2. Inhibits IL-1β-induced PGE2 synthesis in vitro.
Licensing InformationSold for research purposes under agreement from Pfizer Inc.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Mbalaviele et al (2010) Distinction of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition from cyclooxygenase-2 inhibition in cells using a novel, selective mPGES-1 inhibitor. Biochem.Pharmacol. 79 1445. PMID: 20067770.
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Keywords: PF 9184, supplier, PF9184, potent, microsomal, prostaglandins-E, synthases, mPGES-1, inhibitors, inhibits, Tocris Bioscience, Other Isomerase Inhibitor products