Cat. No. 5917
Chemical Name: N-[3',4'-Dichloro(1,1'-biphenyl)-yl]-4
Biological ActivityPotent microsomal prostaglandin E synthase 1 (mPGES-1) inhibitor (IC50 values are 16.5 and 1080 nM for human and rat mPGES-1, respectively). Exhibits >6500-fold selectivity for mPGES-1 over COX-1 and COX-2. Inhibits IL-1β-induced PGE2 synthesis in vitro.
Licensing InformationSold for research purposes under agreement from Pfizer Inc.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Mbalaviele et al (2010) Distinction of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition from cyclooxygenase-2 inhibition in cells using a novel, selective mPGES-1 inhibitor. Biochem.Pharmacol. 79 1445. PMID: 20067770.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses PF 9184 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: PF 9184, supplier, PF9184, potent, microsomal, prostaglandins-E, synthases, mPGES-1, inhibitors, inhibits, Tocris Bioscience, Other Isomerase Inhibitor products
Find multiple products by catalog number
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.