Cat. No. 5916
Alternative Names: CI 1033, PD 183805
Chemical Name: N-[4-[(3-Chloro-4-fluorophenyl)amin
Biological ActivityPotent EGFR kinase inhibitor (IC50 = 7.4 nM). Blocks autophosphorylation of erbB2. Inhibits growth of A431 tumor xenografts in mice. Cell permeable.
Licensing InformationSold for research purposes under agreement from Pfizer Inc.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Smaill et al (2000) Tyrosine kinase inhibitors. 17. Irreversible inhibitors of the epidermal growth factor receptor: 4-(phenylamino)quinazoline- and 4-(phenylamino)pyrido[3,2-d]pyrimidine-6-acrylamides bearing additional solubilizing functions. J.Med.Chem. 43 1380. PMID: 10753475.
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Keywords: Canertinib dihydrochloride, supplier, potent, EGFR, receptor, tyrosine, kinase, epidermal, growth, factor, RTK, anticancer, inhibitors, inhibits, PD183805, CI1033, Tocris Bioscience, EGFR Inhibitor products
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