Canertinib dihydrochloride

Cat. No. 5916new

Canertinib dihydrochloride C24H25ClFN5O3.2HCl [289499-45-2]

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Alternative Names: CI 1033, PD 183805

Chemical Name: N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-2-propenamide dihydrochloride

Biological Activity

Potent EGFR kinase inhibitor (IC50 = 7.4 nM). Blocks autophosphorylation of erbB2. Inhibits growth of A431 tumor xenografts in mice. Cell permeable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

Soluble to 20 mM in water and to 100 mM in DMSO
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Smaill et al (2000) Tyrosine kinase inhibitors. 17. Irreversible inhibitors of the epidermal growth factor receptor: 4-(phenylamino)quinazoline- and 4-(phenylamino)pyrido[3,2-d]pyrimidine-6-acrylamides bearing additional solubilizing functions. J.Med.Chem. 43 1380. PMID: 10753475.

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Keywords: Canertinib dihydrochloride, supplier, potent, EGFR, receptor, tyrosine, kinase, epidermal, growth, factor, RTK, anticancer, inhibitors, inhibits, PD183805, CI1033, Tocris Bioscience, EGFR Inhibitor products

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