Cat. No. 5916
Alternative Names: CI 1033, PD 183805
Chemical Name: N-[4-[(3-Chloro-4-fluorophenyl)amin
Biological ActivityPotent EGFR kinase inhibitor (IC50 = 7.4 nM). Blocks autophosphorylation of erbB2. Inhibits growth of A431 tumor xenografts in mice. Cell permeable.
Licensing InformationSold for research purposes under agreement from Pfizer Inc.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Smaill et al (2000) Tyrosine kinase inhibitors. 17. Irreversible inhibitors of the epidermal growth factor receptor: 4-(phenylamino)quinazoline- and 4-(phenylamino)pyrido[3,2-d]pyrimidine-6-acrylamides bearing additional solubilizing functions. J.Med.Chem. 43 1380. PMID: 10753475.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Canertinib dihydrochloride from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: Canertinib dihydrochloride, supplier, potent, EGFR, receptor, tyrosine, kinase, epidermal, growth, factor, RTK, anticancer, inhibitors, inhibits, PD183805, CI1033, Tocris Bioscience, EGFR Inhibitor products
Find multiple products by catalog number
New Products in this Area
Selective TrkB receptor agonist; neuroprotectantAV 412
Potent inhibitor of EGFR, ErbB2 and Abl receptor tyrosine kinasesCP 724714
Potent and selective ErbB2 inhibitorMitoglitazone
Insulin sensitizer; exhibits low binding affinity at PPARγPF 6274484
High affinity and potent covalent EGFR kinase inhibitorCHMFL-FLT3-122
Potent and selective FLT3 inhibitor
December 13 - 15, 2016