PF 04449613

Cat. No. 5915

PF 04449613 C21H25N5O3 [1236858-52-8]

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Alternative Name: PF 9613

Chemical Name: 1,5-Dihydro-6-[(1R)-1-(3-phenoxy-1-azetidinyl)ethyl]-1-(tetrahydro-2H-pyran-4-yl)-4H-pyrazolo[3,4-d]pyrimidin-4-one

Biological Activity

Potent PDE9 inhibitor (IC50 = 22 nM). Also exhibits a high affinity for cGMP (Km ~170 nM). Brain penetrant.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M.Wt:
395.45
Formula:
C21H25N5O3
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in 1eq. HCl with gentle warming
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
1236858-52-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Lee et al (2015) Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease. Nature 519 472. PMID: 25799991.

Claffey et al (2012) Application of structure-based drug design and parallel chemistry to identify selective, brain penetrant, in vivo active phosphodiesterase 9A inhibitors. J.Med.Chem. 55 9055. PMID: 23025719.

Kleiman et al (2012) Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo. J.Pharmacol.Exp.Ther. 341 396. PMID: 22328573.

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Keywords: PF 04449613, supplier, PF04449613, PF9613, phosphodiesterases, PDE, A, inhibitors, inhibits, potent, Schizophrenia, Alzheimer's, disease, brain, penetrant, Tocris Bioscience, Phosphodiesterase Inhibitor products

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