HEMADO

Cat. No. 1579

HEMADO C17H23N5O4 [403842-38-6]

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Chemical Name: 2-(1-Hexynyl)-N-methyladenosine

Biological Activity

High affinity and selective adenosine A3 receptor agonist (Ki values are 1.1, 327, 1230 and > 30,000 nM for human A3, A1, A2A and A2B receptors respectively).

Technical Data

M.Wt:
361.4
Formula:
C17H23N5O4
Solubility:
Soluble to 100 mM in ethanol and to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
403842-38-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Klotz et al (2006) [3H]HEMADO- a novel tritated agonist selective for the human adenosine A3-receptor. Eur.J.Pharmacol. 556 14. PMID: 17126322.

Volpini et al (2002) N6-Alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A3 receptor and a starting point for searching A2B ligands J.Med.Chem. 45 3271. PMID: 12109910.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for HEMADO include:

Stoddart et al (2012) Fragment screening at adenosine-A(3) receptors in living cells using a fluorescence-based binding assay. Chem Biol 19 1105. PMID: 22999879.

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Keywords: HEMADO, supplier, High, affinity, selective, A3, agonists, Receptors, adenosines, Tocris Bioscience, A3 Receptor Agonist products

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