Cat. No. 1579
Chemical Name: 2-(1-Hexynyl)-N-methyladenosine
Biological ActivityHigh affinity and selective adenosine A3 receptor agonist (Ki values are 1.1, 327, 1230 and > 30,000 nM for human A3, A1, A2A and A2B receptors respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Klotz et al (2006) [3H]HEMADO- a novel tritated agonist selective for the human adenosine A3-receptor. Eur.J.Pharmacol. 556 14. PMID: 17126322.
Volpini et al (2002) N6-Alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A3 receptor and a starting point for searching A2B ligands J.Med.Chem. 45 3271. PMID: 12109910.
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Citations are publications that use Tocris products. Selected citations for HEMADO include:
Stoddart et al (2012) Fragment screening at adenosine-A(3) receptors in living cells using a fluorescence-based binding assay. Chem Biol 19 1105. PMID: 22999879.
Gomez et al (2011) Disparity in FcηRI-induced degranulation of primary human lung and skin mast cells exposed to adenosine. Mol Cell Proteomics 31 479. PMID: 21437670.
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Keywords: HEMADO, supplier, High, affinity, selective, A3, agonists, Receptors, adenosines, Tocris Bioscience, Adenosine A3 Receptor Agonist products