RMM 46

Cat. No. 5909new

RMM 46 C24H26N4O5 [1307896-46-3]

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Chemical Name: 2-Cyano-N-(2-hydroxy-1,1-dimethylethyl)-3-[3-(3,4,5-trimethoxyphenyl)-1H-indazol-5-yl]-2-propenamide

Biological Activity

MSK/RSK family kinase inhibitor. Exhibits selectivity for RSK2 over NEK2 and PLK1 (IC50s are 12, 530 and 2200 nM, respectively). Inhibits MSK1, MSK2, RSK2 and RSK3 in cellular assays. Reduces CREB phosphorylation in HeLa cells.

Technical Data

M.Wt:
450.5
Formula:
C24H26N4O5
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
1307896-46-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Miller et al (2013) Electrophilic fragment-based design of reversible covalent kinase inhibitors. J.Am.Chem.Soc. 135 5298. PMID: 23540679.

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Citations are publications that use Tocris products.

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Keywords: RMM 46, supplier, RMM46, RSK2, 3, MSK1, inhibitors, inhibits, family, kinases, CREB, phosphorylation, Tocris Bioscience, RSK Inhibitor products

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