Bis-ANS

Cat. No. 5908

Bis-ANS C32H22K2N2O6S2 [65664-81-5]

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Chemical Name: 4,4'-Bis(phenylamino)-[1,1'-binaphthalene]-5,5'-disulfonic acid dipotassium salt

Biological Activity

Fluorescent probe for nonpolar cavities in proteins. Used to detect Aβ fibre (Kd = ~80 nM); exhibits distinct fluorescent profiles for fibres and oligomers. Fluoresces in hydrophobic environments, negligible fluorescence in water solutions. Excitation\emission λ ~ 355\520 nm at pH 7.4.

Technical Data

M.Wt:
672.85
Formula:
C32H22K2N2O6S2
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in water
Purity:
>97 %
Storage:
Store at RT
CAS No:
65664-81-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Younan et al (2015) A comparison of three fluorophores for the detection of amyloid fibers and prefibrillar oligomeric assemblies. ThT (Thioflavin T); ANS (1-Anilinonaphthalene-8-sulfonic Acid); and bisANS (4,4'-Dianilino-1,1'-binaphthyl-5,5'-disulfonic Acid). Biochemistry 54 4297. PMID: 26087242.

Rosen et al (1969) Dimer formation from 1-amino-8-naphthalenesulfonate catalyzed by bovine serum albumin. A new fluorescent molecule with exceptional binding properties. Biochemistry 8 3915. PMID: 5388144.

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Citations are publications that use Tocris products.

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Keywords: Bis-ANS, supplier, Amyloid, β, Aβ, peptides, fibers, fibres, oligomers, oligomeric, fluorescent, probe, detects, Tocris Bioscience, Fluorescent Probe products

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