Cat. No. 5907
Alternative Names: MK 0457, Tozasertib
Chemical Name: N-[4-[[4-(4-Methyl-1-piperazinyl)-6
Biological ActivityHigh affinity and selective Aurora kinase inhibitor (Ki values are 0.6, 5 and 18 nM for Aurora A, Aurora C and Aurora B, respectively). Also exhibits affinity for FLT-3 and Abl. Exhibits selectivity for Aurora kinase over 190 other protein kinases. Inhibits proliferation and induces apoptosis in a number of cancer cell lines in vitro. Reduces tumor size in leukemia and colon cancer cell xenografts in mice.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Bebbington et al (2009) The discovery of the potent aurora inhibitor MK-0457 (VX-680). Bioorg.Med.Chem.Lett. 19 3586. PMID: 19447622.
Harrington et al (2004) VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo. Nat.Med. 10 262. PMID: 14981513.
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Keywords: VX 680, supplier, VX680, MK0457, high, affinity, selective, aurora, kinases, inhibitors, inhibits, AurA, AurB, AurC, Tocris Bioscience, Aurora Kinase Inhibitor products
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