Cat. No. 5906
Alternative Names: Gleevec, CGP 57148B
Chemical Name: 4-[(4-Methyl-1-piperazinyl)methyl]-
Biological ActivityPotent and selective v-Abl tyrosine kinase inhibitor (IC50 = 38 nM). Also inhibits PDGFR and c-kit. Exhibits selectivity for v-Abl over a panel of other tyrosine and serine/threonine protein kinases. Selectively inhibits PDGF-stimulated growth of v-abl-transformed PB-3 cells and v-sis-transformed BALB/c 3T3 cells in vitro. Exhibits antitumor effects in mice bearing AMuLV or BABL/c 3T3 v-sis cells.
External Portal InformationChemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of Imatinib is reviewed on the chemical probes website.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Juurikivi et al (2005) Inhibition of c-kit tyrosine kinase by imatinib mesylate induces apoptosis in mast cells in rheumatoid synovia: a potential approach to the treatment of arthritis. Ann.Rheum.Dis. 64 1126. PMID: 16014680.
Buchdunger et al (1996) Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative. Cancer Res. 56 100. PMID: 8548747.
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Keywords: Imatinib mesylate, supplier, potent, selective, v-ABL, tyrosine, kinases, inhibitors, inhibits, anticancer, leukemia, leukaemia, CGP57148B, platelet-derived, growth, factor, receptors, PDGFRs, ckit, Tocris Bioscience, Abl Kinase Inhibitor products
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