Montelukast sodium

Cat. No. 5904

Montelukast sodium C35H35ClNNaO3S [151767-02-1]

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Chemical Name: 1-[[[(1R)-1-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid sodium salt

Biological Activity

Cysteinyl leukotriene receptor 1 (CysLT1) and GPR17 antagonist. Blocks pentylenetetrazole-induced seizures, blood brain barrier (BBB) disruption and leukocyte migration in mice. Reduces neuroinflammation, improves BBB integrity, enhances learning and memory, and restores hippocampal neurogenesis and cognitive function in aged rats. Orally active and brain penetrant.

Technical Data

M.Wt:
608.17
Formula:
C35H35ClNNaO3S
Solubility:
Soluble to 50 mM in water and to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
151767-02-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Marschallinger et al (2015) Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug. Nat.Commun. 6 8466. PMID: 26506265 .

Lenz et al (2014) Cysteinyl leukotriene receptor (CysLT) antagonists decrease pentylenetetrazol-induced seizures and blood-brain barrier dysfunction. Neuroscience 277 859. PMID: 25090924.

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Keywords: Montelukast sodium, supplier, Leukotriene, D4, antagonists, antagonism, cysteinyl, receptors, CysLT1, seizures, blood, brain, barrier, disruption, epilepsy, GPR17, Tocris Bioscience, Leukotriene and Related Receptor Antagonist products

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