Cat. No. 5904
Chemical Name: 1-[[[(1R)-1-[3-[(1E)-2-(7-Chloro-2-
Biological ActivityCysteinyl leukotriene receptor 1 (CysLT1) and GPR17 antagonist. Blocks pentylenetetrazole-induced seizures, blood brain barrier (BBB) disruption and leukocyte migration in mice. Reduces neuroinflammation, improves BBB integrity, enhances learning and memory, and restores hippocampal neurogenesis and cognitive function in aged rats. Orally active and brain penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Marschallinger et al (2015) Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug. Nat.Commun. 6 8466. PMID: 26506265 .
Lenz et al (2014) Cysteinyl leukotriene receptor (CysLT) antagonists decrease pentylenetetrazol-induced seizures and blood-brain barrier dysfunction. Neuroscience 277 859. PMID: 25090924.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Montelukast sodium from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: Montelukast sodium, supplier, Leukotriene, D4, antagonists, antagonism, cysteinyl, receptors, CysLT1, seizures, blood, brain, barrier, disruption, epilepsy, GPR17, Tocris Bioscience, Leukotriene and Related Receptor Antagonist products
Find multiple products by catalog number
New Products in this Area
Selective GPR84 agonistIHR-Cy3
Potent fluorescent Smo antagonistRo 6842262
Potent LPA1 antagonistAMG 853
Potent dual CRTH2 and prostaglandin D2 (PGD2) receptor antagonistAM 4668
Potent FFA1 (GPR40) agonistCATPB
FFA2 antagonist/inverse agonistOleanolic acid
Selective GPBA receptor (TGR5) partial agonistPPTN hydrochloride
High affinity and selective P2Y14 antagonistItraconazole
SMO antagonist; acts at different binding site to cyclopamine (Cat No. 1623)SAR 216471 hydrochloride
Potent P2Y12 antagonist; orally available
March 18 - 22, 2017
Little Rock, ARK, USA