Cat. No. 5904
Chemical Name: 1-[[[(1R)-1-[3-[(1E)-2-(7-Chloro-2-
Biological ActivityCysteinyl leukotriene receptor 1 (CysLT1) and GPR17 antagonist. Blocks pentylenetetrazole-induced seizures, blood brain barrier (BBB) disruption and leukocyte migration in mice. Reduces neuroinflammation, improves BBB integrity, enhances learning and memory, and restores hippocampal neurogenesis and cognitive function in aged rats. Orally active and brain penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Marschallinger et al (2015) Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug. Nat.Commun. 6 8466. PMID: 26506265 .
Lenz et al (2014) Cysteinyl leukotriene receptor (CysLT) antagonists decrease pentylenetetrazol-induced seizures and blood-brain barrier dysfunction. Neuroscience 277 859. PMID: 25090924.
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Keywords: Montelukast sodium, supplier, Leukotriene, D4, antagonists, antagonism, cysteinyl, receptors, CysLT1, seizures, blood, brain, barrier, disruption, epilepsy, GPR17, Tocris Bioscience, Leukotriene and Related Receptor Antagonist products
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