Cat. No. 5903new

CATPB C19H17ClF3NO3 [1322598-09-3]

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Chemical Name: (S)-3-(2-(3-Chlorophenyl)acetamido)-4-(4-(trifluoromethyl)phenyl)butanoic acid

Biological Activity

FFA2 antagonist/inverse agonist (pKi = 7.87). Selective for human over mouse FFA2. Increases forskolin-induced cAMP production and inhibits acetate-induced MAPK signaling in cells expressing human FFA2.

Technical Data

Soluble to 100 mM in DMSO and to 50 mM in ethanol
>98 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Park et al (2016) Selective novel inverse agonists for human GPR43 augment GLP-1 secretion. Eur.J.Pharmacol. 771 1. PMID: 26683635 .

Sergeev et al (2016) Non-equivalence of key positively charged residues of the free fatty acid 2 receptor in the recognition and function of agonist versus antagonist ligands. J.Biol.Chem. 291 303. PMID: 26518871 .

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Keywords: CATPB, supplier, free, fatty, acids, receptors, FFA2, antagonists, inverse, agonists, antagonism, agonism, short, chain, SCFA, Tocris Bioscience, Free Fatty Acid Receptor Antagonist products

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