CATPB

Cat. No. 5903

CATPB C19H17ClF3NO3 [1322598-09-3]

Price and Availability

For CATPB pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: (S)-3-(2-(3-Chlorophenyl)acetamido)-4-(4-(trifluoromethyl)phenyl)butanoic acid

Biological Activity

FFA2 antagonist/inverse agonist (pKi = 7.87). Selective for human over mouse FFA2. Increases forskolin-induced cAMP production and inhibits acetate-induced MAPK signaling in cells expressing human FFA2.

Technical Data

M.Wt:
399.79
Formula:
C19H17ClF3NO3
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
>98 %
Storage:
Store at RT
CAS No:
1322598-09-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Park et al (2016) Selective novel inverse agonists for human GPR43 augment GLP-1 secretion. Eur.J.Pharmacol. 771 1. PMID: 26683635 .

Sergeev et al (2016) Non-equivalence of key positively charged residues of the free fatty acid 2 receptor in the recognition and function of agonist versus antagonist ligands. J.Biol.Chem. 291 303. PMID: 26518871 .

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses CATPB from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: CATPB, supplier, free, fatty, acids, receptors, FFA2, antagonists, inverse, agonists, antagonism, agonism, short, chain, SCFA, Tocris Bioscience, Free Fatty Acid Receptor Antagonist products

Quick Order

Find multiple products by catalog number

divider line

GPCR Product Listing

GPCR Product Listing

Highlights over 450 products for GPCRs. Request copy or view PDF today.

divider line

New Products in this Area

AR-C 69931 tetrasodium salt

Highly potent P2Y12 antagonist

FTY 720

Potent S1P receptor agonist; also immunosuppresent

Cinacalcet hydrochloride

Calcium-sensing receptor (CaSR) allosteric agonist; also CYP2D2 inhibitor and Ca2+ channel blocker; orally bioavailable

AMG 837 hemicalcium salt

Potent free fatty acid receptor 1 (FFA1/GPR40) partial agonist

UMB 68

GHB receptor ligand

AZD 1283

High affinity P2Y12 antagonist

Ex 26

Potent and selective S1P1 receptor antagonist

ZQ 16

Selective GPR84 agonist

IHR-Cy3

Potent fluorescent Smo antagonist

Ro 6842262

Potent LPA1 antagonist

AMG 853

Potent dual CRTH2 and prostaglandin D2 (PGD2) receptor antagonist

AM 4668

Potent FFA1 (GPR40) agonist

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.