Cat. No. 5903
Chemical Name: (S)-3-(2-(3-Chlorophenyl)acetamido)
Biological ActivityFFA2 antagonist/inverse agonist (pKi = 7.87). Selective for human over mouse FFA2. Increases forskolin-induced cAMP production and inhibits acetate-induced MAPK signaling in cells expressing human FFA2.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Park et al (2016) Selective novel inverse agonists for human GPR43 augment GLP-1 secretion. Eur.J.Pharmacol. 771 1. PMID: 26683635 .
Sergeev et al (2016) Non-equivalence of key positively charged residues of the free fatty acid 2 receptor in the recognition and function of agonist versus antagonist ligands. J.Biol.Chem. 291 303. PMID: 26518871 .
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Keywords: CATPB, supplier, free, fatty, acids, receptors, FFA2, antagonists, inverse, agonists, antagonism, agonism, short, chain, SCFA, Tocris Bioscience, Free Fatty Acid Receptor Antagonist products
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