Cat. No. 5902
Alternative Name: Ba 679 BR
Chemical Name: (1α,2β,4β,5α,7β)-7-[(2-Hydroxy-2,2-di-2-
Biological ActivityPotent muscarinic receptor antagonist. Inhibits electrical field stimulation-induced contraction of guinea pig trachea in vitro (IC50 = 0.17 nM). Induces smooth muscle relaxation and bronchodilation.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Smit et al (2014) Bronchoprotection by olodaterol is synergistically enhanced by tiotropium in a guinea pig model of allergic asthma. J.Pharmacol.Exp.Ther. 348 303. PMID: 24307202.
Ogoda et al (2011) Comparative characterization of lung muscarinic receptor binding after intratracheal administration of tiotropium, ipratropium, and glycopyrrolate. J.Pharm.Sci. 115 374. PMID: 21358117.
Takahashi et al (1994) Effect of Ba 679 BR, a novel long-acting anticholinergic agent, on cholinergic neurotransmission in guinea pig and human airways. Am.J.Respir.Crit.Care Med. 150 1640. PMID: 7952627.
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Keywords: Tiotropium bromide, supplier, Ba679BR, potent, muscarinic, receptors, antagonists, M1, M2, M3, M4, Tocris Bioscience, Non-selective Muscarinic Antagonist products
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