Tiotropium bromide

Cat. No. 5902

Tiotropium bromide C19H22BrNO4S2 [136310-93-5]

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Alternative Name: Ba 679 BR

Chemical Name: (1α,2β,4β,5α,7β)-7-[(2-Hydroxy-2,2-di-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide

Biological Activity

Potent muscarinic receptor antagonist. Inhibits electrical field stimulation-induced contraction of guinea pig trachea in vitro (IC50 = 0.17 nM). Induces smooth muscle relaxation and bronchodilation.

Technical Data

M.Wt:
472.42
Formula:
C19H22BrNO4S2
Solubility:
Soluble to 20 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
136310-93-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Smit et al (2014) Bronchoprotection by olodaterol is synergistically enhanced by tiotropium in a guinea pig model of allergic asthma. J.Pharmacol.Exp.Ther. 348 303. PMID: 24307202.

Ogoda et al (2011) Comparative characterization of lung muscarinic receptor binding after intratracheal administration of tiotropium, ipratropium, and glycopyrrolate. J.Pharm.Sci. 115 374. PMID: 21358117.

Takahashi et al (1994) Effect of Ba 679 BR, a novel long-acting anticholinergic agent, on cholinergic neurotransmission in guinea pig and human airways. Am.J.Respir.Crit.Care Med. 150 1640. PMID: 7952627.

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Citations are publications that use Tocris products.

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Keywords: Tiotropium bromide, supplier, Ba679BR, potent, muscarinic, receptors, antagonists, M1, M2, M3, M4, Tocris Bioscience, Non-selective Muscarinic Antagonist products

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