c-Di-AMP sodium salt

Cat. No. 5901

c-Di-AMP sodium salt C20H22N10Na2O12P2

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Chemical Name: 3',5'-Cyclic diadenylic acid sodium salt

Biological Activity

Endogenous STING and DDX41 agonist; mediates DDX41-STING interaction. Activates STING-dependent IFN-β production in mouse and human cells. Also A2A inverse agonist. Selectively induces apoptosis of monocytes in human PBMC cultures and in NSG mice transplanted with human CD34+ cells.

Technical Data

M.Wt:
702.38
Formula:
C20H22N10Na2O12P2
Solubility:
Soluble to 20 mM in water
Purity:
>98 %
Storage:
Store at -20°C

Resources

Other Information

  • This product is sold in units of 702μg, equivalent to 1μmol.

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Tosolini et al (2015) Human monocyte recognition of adenosine-based cyclic dinucleotides unveils the A2a Gαs protein-coupled receptor tonic inhibition of mitochondrially induced cell death. Mol.Cell.Biol. 35 479. PMID: 25384972 .

Parvatiyar et al (2012) The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response. Nat.Immunol. 13 1155. PMID: 23142775.

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Keywords: c-Di-AMP sodium salt, supplier, STING, DDX41, ligands, activates, activators, adenosine, A2A, receptors, inverse, agonists, agonism, apoptosis, Tocris Bioscience, STING-Dependent Signaling Agonist products

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