c-Di-GMP sodium salt
Cat. No. 5900
Chemical Name: 3',5'-Cyclic diguanylic acid sodium salt
Biological ActivityEndogenous STING and DDX41 agonist; mediates DDX41-STING interaction. Activates STING-dependent IFN-β production in mouse and human cells. Also induces an antitumor response in a lung B16-10 melanoma mouse model, when administered intravenously within YSKO5-liposomes.
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Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Nakamura et al (2015) Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanoma. J.Control Release 216 149. PMID: 26282097.
Parvatiyar et al (2012) The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response. Nat.Immunol. 13 1155. PMID: 23142775.
Burdette et al (2011) STING is a direct innate immune sensor of cyclic di-GMP. Nature 478 515. PMID: 21947006.
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Keywords: c-Di-GMP sodium salt, supplier, STING, DDX41, ligands, activates, activators, cancer, immunotherapy, 61093-23-0, Tocris Bioscience, STING-Dependent Signaling Agonist products
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