c-Di-GMP sodium salt

Cat. No. 5900

c-Di-GMP sodium salt C20H22N10Na2O14P2

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Chemical Name: 3',5'-Cyclic diguanylic acid sodium salt

Biological Activity

Endogenous STING and DDX41 agonist; mediates DDX41-STING interaction. Activates STING-dependent IFN-β production in mouse and human cells. Also induces an antitumor response in a lung B16-10 melanoma mouse model, when administered intravenously within YSKO5-liposomes.

Technical Data

Soluble to 20 mM in water
>98 %
Store at -20°C


Other Information

  • This product is sold in units of 730μg, equivalent to 1μmol.

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Nakamura et al (2015) Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanoma. J.Control Release 216 149. PMID: 26282097.

Parvatiyar et al (2012) The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response. Nat.Immunol. 13 1155. PMID: 23142775.

Burdette et al (2011) STING is a direct innate immune sensor of cyclic di-GMP. Nature 478 515. PMID: 21947006.

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Citations are publications that use Tocris products.

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Keywords: c-Di-GMP sodium salt, supplier, STING, DDX41, ligands, activates, activators, cancer, immunotherapy, 61093-23-0, Tocris Bioscience, STING-Dependent Signaling Agonist products

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