pCPA methyl ester hydrochloride
Cat. No. 5871
Chemical Name: 4-Chloro-DL-Phenylalanine methyl ester hydrochloride
Biological ActivityTryptophan hydroxylase inhibitor. Inhibits 5-HT synthesis. Depletes 5-HT levels in orbitofrontal cortex and impairs reversal learning in rats. Methyl ester of p-Chlorophenylalanine (Cat. No. 0938).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Pinto Brod et al (2016) Involvement of monoaminergic system in the antidepressant-like effect of (octylseleno)-xylofuranoside in the mouse tail suspension test. Prog.Neuropsychopharmacol.Biol.Psychiatry. 65 201. PMID: 26596986.
Wallace et al (2014) Vortioxetine restores reversal learning impaired by 5-HT depletion or chronic intermittent cold stress in rats. Int.J.Neuropsychopharmacol. 17 1695. PMID: 24852131.
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Keywords: pCPA methyl ester hydrochloride, supplier, tryptophan, hydroxylase, inhibitors, inhibits, serotonin, 5-HT, depletion, depletes, synthesis, Tocris Bioscience, Hydroxylase Inhibitor products
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