Cilengitide

Cat. No. 5870new

Cilengitide cyclo(Arg-Gly-Asp-D-Phe-(NMe)-Val)

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Alternative Name: EMD121974

Biological Activity

Potent and selective inhibitor of integrins αvβ3 and αvβ5 (IC50 values are 4.1 and 70 nM, respectively). Exhibits ~10-fold selectivity over gpIIb/IIIa. Increases endothelial monolayer permeability. Also exhibits antiangiogenic activity.

Technical Data

M.Wt:
588.66
Formula:
C27H40N8O7
Sequence:
RGDFV

(Modifications: Phe-4 = D-Phe, Val-5 = Me-Val, Cyclizedl)

Solubility:
Soluble to 10 mg/ml in water
Storage:
Store at -20°C
CAS No:
188968-51-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Alghisi et al (2009) The integrin antagonist cilengitide activates αvβ3, disrupts VE-cadherin localization at cell junctions and enhances permeability in endothelial cells. PLoS One 4 e4449. PMID: 19212436.

Monnier et al (2008) CYR61 and αvβ5 integrin cooperate to promote invasion and metastasis of tumors growing in preirradiated stroma. Cancer Res. 68 7323. PMID: 18794119.

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Keywords: Cilengitide, supplier, Potent, selective, inhibitors, inhibits, integrin, αvβ3, αvβ5, alphavbeta3, alphavbeta5, Tocris Bioscience, Integrin Receptor Inhibitor products

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