CDN 1163

Cat. No. 5869new

CDN 1163 C20H20N2O2 [892711-75-0]

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Chemical Name: 4-(1-Methylethoxy)-N-(2-methyl-8-quinolinyl)benzamide

Biological Activity

SERCA2 allosteric activator. Increases Ca2+-ATPase activity and Ca2+ uptake by ER microsomes from obese mice. Rescues HEK cells from ER stress-induced cell death. Reduces fasting glucose levels and adipose tissue weight, and increases energy expenditure in ob/ob mice. Also mproves glucose tolerance and reverses hepatic steatosis in ob/ob mice.

Technical Data

M.Wt:
320.38
Formula:
C20H20N2O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at RT
CAS No:
892711-75-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Kang et al (2016) Small molecular allosteric activator of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) attenuates diabetes and metabolic disorders. J.Biol.Chem. 291 5185. PMID: 26702054.

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Keywords: CDN 1163, supplier, CDN1163, allosteric, activators, sarco/endoplasmic, reticulum, Ca2+-ATPase, activates, ER, stress, SERCA2b, type, II, diabetes, T2D, Tocris Bioscience, Ca2+-ATPase Activator products

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