CDN 1163

Cat. No. 5869

CDN 1163 C20H20N2O2 [892711-75-0]

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Chemical Name: 4-(1-Methylethoxy)-N-(2-methyl-8-quinolinyl)benzamide

Biological Activity

SERCA2 allosteric activator. Increases Ca2+-ATPase activity and Ca2+ uptake by ER microsomes from obese mice. Rescues HEK cells from ER stress-induced cell death. Reduces fasting glucose levels and adipose tissue weight, and increases energy expenditure in ob/ob mice. Also improves glucose tolerance and reverses hepatic steatosis in ob/ob mice.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
>98 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Kang et al (2016) Small molecular allosteric activator of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) attenuates diabetes and metabolic disorders. J.Biol.Chem. 291 5185. PMID: 26702054.

If you know of a relevant reference for CDN 1163 please let us know.

Citations are publications that use Tocris products. Selected citations for CDN 1163 include:

Ferdek et al (2017) BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides. Cell.Death.Dis. 8. PMID: 28252652.

Do you know of a great paper that uses CDN 1163 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: CDN 1163, supplier, CDN1163, allosteric, activators, sarco/endoplasmic, reticulum, Ca2+-ATPase, activates, ER, stress, SERCA2b, type, II, diabetes, T2D, Tocris Bioscience, Ca2+-ATPase Activator products

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