Cat. No. 5869
Chemical Name: 4-(1-Methylethoxy)-N-(2-methyl-8-qu
Biological ActivitySERCA2 allosteric activator. Increases Ca2+-ATPase activity and Ca2+ uptake by ER microsomes from obese mice. Rescues HEK cells from ER stress-induced cell death. Reduces fasting glucose levels and adipose tissue weight, and increases energy expenditure in ob/ob mice. Also mproves glucose tolerance and reverses hepatic steatosis in ob/ob mice.
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Certificate of Analysis / Product Datasheet / Safety Data Sheet
Kang et al (2016) Small molecular allosteric activator of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) attenuates diabetes and metabolic disorders. J.Biol.Chem. 291 5185. PMID: 26702054.
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Keywords: CDN 1163, supplier, CDN1163, allosteric, activators, sarco/endoplasmic, reticulum, Ca2+-ATPase, activates, ER, stress, SERCA2b, type, II, diabetes, T2D, Tocris Bioscience, Ca2+-ATPase Activator products