Ceefourin 1

Cat. No. 5867

Ceefourin 1 C11H10N4S3 [315702-40-0]

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Chemical Name: 5-[(2-Benzothiazolylthio)methyl]-2,4-dihydro-4-methyl-3H-1,2,4-triazole-3-thione

Biological Activity

Selective MRP (multidrug resistance-associated protein) 4 inhibitor (IC50 = 2.6 μM). Selective for MRP4 over P-gp, MRP1 and ABCG2. Sensitizes MRP4 over-expressing cells to SN 38 (Cat. No. 2684).

Technical Data

M.Wt:
294.42
Formula:
C11H10N4S3
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
315702-40-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Cheung et al (2014) High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4). Biochem.Pharmacol. 91 97. PMID: 24973542.

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Keywords: Ceefourin 1, supplier, multidrug, resistance-associated, protein, 4, MRP4, inhibitors, inhibits, transporter, Tocris Bioscience, Multidrug Transporter Inhibitor products

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