KLH 45

Cat. No. 5865new

KLH 45 C24H25F3N4O2 [1632236-44-2]

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Chemical Name: N-Cyclohexyl-N-(2-phenylethyl)-4-[4-(trifluoromethoxy)phenyl]-2H-1,2,3-triazole-2-carboxamide

Biological Activity

Potent DDHD2 inhibitor (IC50 = 1.3 nM). Selective for DDHD2 over 40 other serine hydrolases, but does exhibit cross-reactivity with ABHD6. Active n vivo. Increases brain triacylglycerol levels in mice.

Licensing Information

Sold under license from The Scripps Research Institute

Technical Data

M.Wt:
458.48
Formula:
C24H25F3N4O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
1632236-44-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Inloes et al (2014) The hereditary spastic paraplegia-related enzyme DDHD2 is a principal brain triglyceride lipase. Proc.Natl.Acad.Sci.U.S.A. 111 14924. PMID: 25267624 .

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Keywords: KLH 45, supplier, KLH45, DDHD2, inhibits, inhibitors, potent, in, vivo, active, serine, hydrolase, Tocris Bioscience, Other Hydrolase Inhibitor products

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