Ritonavir

Cat. No. 5856new

Ritonavir C37H48N6O5S2 [155213-67-5]

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Alternative Names: ABT-538, A-84538, Abbot 84538

Chemical Name: 5-Thiazolylmethyl (3S,4S,6S,9S)-4-hydroxy-12-methyl-9-(1-methylethyl)-13-[2-(1-methylethyl)-4-thiazolyl]-8,11-dioxo-3,6-bis(phenylmethyl)-2,7,10,12-tetraazatridecanoate

Biological Activity

HIV-1 and HIV-2 protease inhibitor (EC50 values are 0.022-0.13 and 0.16 μM, respectively). Blocks the metabolism of protease inhibitors by liver enzyme cytochrome P450-3A4 (CYP3A4). Orally bioavailable.

Technical Data

M.Wt:
720.94
Formula:
C37H48N6O5S2
Solubility:
Soluble to 20 mM in DMSO with gentle warming and to 10 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
155213-67-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Zeldin et al (2004) Pharmacological and therapeutic properties of ritonavir-boosted protease inhibitor therapy in HIV-infected patients. J.Antimicrob.Chemother. 53 4. PMID: 14657084.

Kempf et al (1998) Discovery of ritonavir, a potent inhibitor of HIV protease with high oral bioavailability and clinical efficacy. J.Med.Chem. 41 602. PMID: 9484509.

Kempf et al (1995) ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans. Proc.Natl.Acad.Sci.U.S.A. 92 2484. PMID: 7708670.

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Keywords: Ritonavir, supplier, HIV-1, HIV-2, proteases, inhibitors, inhibits, cytochrome, P450-3A4, human, immunodeficiency, virus, orally, active, Tocris Bioscience, Other Protease Inhibitor products

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