Cat. No. 5856
Alternative Names: ABT-538, A-84538, Abbot 84538
Chemical Name: 5-Thiazolylmethyl (3S,4S,6S,9S)-4-hydroxy-12-methyl-9
Biological ActivityHIV-1 and HIV-2 protease inhibitor (EC50 values are 0.022-0.13 and 0.16 μM, respectively). Blocks the metabolism of protease inhibitors by liver enzyme cytochrome P450-3A4 (CYP3A4). Orally bioavailable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Zeldin et al (2004) Pharmacological and therapeutic properties of ritonavir-boosted protease inhibitor therapy in HIV-infected patients. J.Antimicrob.Chemother. 53 4. PMID: 14657084.
Kempf et al (1998) Discovery of ritonavir, a potent inhibitor of HIV protease with high oral bioavailability and clinical efficacy. J.Med.Chem. 41 602. PMID: 9484509.
Kempf et al (1995) ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans. Proc.Natl.Acad.Sci.U.S.A. 92 2484. PMID: 7708670.
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Citations are publications that use Tocris products.
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Keywords: Ritonavir, supplier, HIV-1, HIV-2, proteases, inhibitors, inhibits, cytochrome, P450-3A4, human, immunodeficiency, virus, orally, active, Tocris Bioscience, Other Protease Inhibitor products
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