Cat. No. 5855
Chemical Name: Ethyl 3-[[[(4-chlorophenyl)methyl][(5-nit
Biological ActivityRev-Erbα/β agonist (EC50 = 710 nM; Kd = 800 nM). Alters circadian locomotor activity and core clock hypothalamic gene expression in mice. Induces weight loss in diet-induced obese mice. Brain penetrant.
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Certificate of Analysis / Product Datasheet / Safety Data Sheet
Shin et al (2012) Small molecule tertiary amines as agonists of the nuclear hormone receptor Rev-erbα. Bioorg.Med.Chem.Lett. 22 4413. PMID: 22633688 .
Solt et al (2012) Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists. Nature 485 62. PMID: 22460951.
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Keywords: SR 9009, supplier, SR9009, Rev-Erbalpha, Rev-Erba, Rev-Erbbeta, Rev-Erbb, Rev-Erbα, Rev-Erbβ, agonists, agonism, circadian, rhythm, antiobesity, brain, penetrant, Tocris Bioscience, Rev-Erb Receptor Agonist products
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