SR 9009

Cat. No. 5855

SR 9009 C20H24ClN3O4S [1379686-30-2]

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Chemical Name: Ethyl 3-[[[(4-chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-1-pyrrolidinecarboxylate

Biological Activity

Rev-Erbα/β agonist (EC50 = 710 nM; Kd = 800 nM). Alters circadian locomotor activity and core clock hypothalamic gene expression in mice. Induces weight loss in diet-induced obese mice. Brain penetrant.

Technical Data

M.Wt:
437.94
Formula:
C20H24ClN3O4S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
1379686-30-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Shin et al (2012) Small molecule tertiary amines as agonists of the nuclear hormone receptor Rev-erbα. Bioorg.Med.Chem.Lett. 22 4413. PMID: 22633688 .

Solt et al (2012) Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists. Nature 485 62. PMID: 22460951.

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Citations are publications that use Tocris products.

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Keywords: SR 9009, supplier, SR9009, Rev-Erbalpha, Rev-Erba, Rev-Erbbeta, Rev-Erbb, Rev-Erbα, Rev-Erbβ, agonists, agonism, circadian, rhythm, antiobesity, brain, penetrant, Tocris Bioscience, Rev-Erb Receptor Agonist products

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