Cat. No. 5854
Chemical Name: Ethyl 5-[[[[3'-(Methylsulfonyl)[1,1'-biphen
Biological ActivityPotent and selective LXR inverse agonist (IC50 values are 43 and 214 nM for LXRβ and LXRα, respectively). Selectively inhibits liver LXR over peripheral LXR. Exhibits selectivity for LXR over a panel of 20 other nuclear receptors, including FXR. Reduces hepatic steatosis in obese mice.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Griffett et al (2013) A liver-selective LXR inverse agonist that suppresses hepatic steatosis. ACS Chem.Biol. 8 559. PMID: 23237488.
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Keywords: SR 9238, supplier, SR9238, potent, selective, LXR, inverse, agonist, liver, obesity, receptors, Tocris Bioscience, LXR-like Receptor Antagonist products
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August 20 - 24, 2017
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