Acetyl Pepstatin

Cat. No. 5852new

Acetyl Pepstatin Ac-Val-Val-(3S,4S)-4-amino-3-hydroxy-6-methylheptanoyl-Ala-(3S,4S)-4-amino-3-hydroxy-6-methylheptanoic-acid

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Biological Activity

High affinity aspartic protease inhibitor. Inhibits HIV-1 protease (Ki = 20 nM at pH 4.7) and HIV-2 protease (Ki = 5 nM at pH 4.7). Antiviral.

Technical Data


(Modifications: Val-1 = N-terminal Ac, Val-2 = Val-(3S,4S)-4-amino-3-hydroxy-6-methylheptanoyl, Ala-3 = Ala-(3S,4S)4-amino-3-hydroxy-6-methylheptanoic-acid)

Soluble to 2 mg/ml in PBS
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Matúz et al (2012) Inhibition of XMRV and HIV-1 proteases by pepstatin A and acetyl-pepstatin. FEBS J. 279 3276. PMID: 22804908.

Richards et al (1989) Effective blocking of HIV-1 proteinase activity by characteristic inhibitors of aspartic proteinases. FEBS Lett. 247 113. PMID: 2651157.

Richards et al (1989) Inhibition of the aspartic proteinase from HIV-2. FEBS Lett. 253 214. PMID: 2668032.

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Keywords: Acetyl Pepstatin, supplier, High, affinity, aspartic, protease, inhibitors, HIV-1, proteinases, HIV-2, antiviral, inhibits, Tocris Bioscience, Other Protease Inhibitor products

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