Acetyl Pepstatin

Cat. No. 5852new

Acetyl Pepstatin Ac-Val-Val-(3S,4S)-4-amino-3-hydroxy-6-methylheptanoyl-Ala-(3S,4S)-4-amino-3-hydroxy-6-methylheptanoic-acid

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Biological Activity

High affinity aspartic protease inhibitor. Inhibits HIV-1 protease (Ki = 20 nM at pH 4.7) and HIV-2 protease (Ki = 5 nM at pH 4.7). Antiviral.

Technical Data

M.Wt:
643.81
Formula:
C31H57N5O9
Sequence:
VVA

(Modifications: Val-1 = N-terminal Ac, Val-2 = Val-(3S,4S)-4-amino-3-hydroxy-6-methylheptanoyl, Ala-3 = Ala-(3S,4S)4-amino-3-hydroxy-6-methylheptanoic-acid)

Solubility:
Soluble to 2 mg/ml in PBS
Storage:
Store at -20°C
CAS No:
11076-29-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Matúz et al (2012) Inhibition of XMRV and HIV-1 proteases by pepstatin A and acetyl-pepstatin. FEBS J. 279 3276. PMID: 22804908.

Richards et al (1989) Effective blocking of HIV-1 proteinase activity by characteristic inhibitors of aspartic proteinases. FEBS Lett. 247 113. PMID: 2651157.

Richards et al (1989) Inhibition of the aspartic proteinase from HIV-2. FEBS Lett. 253 214. PMID: 2668032.

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Keywords: Acetyl Pepstatin, supplier, High, affinity, aspartic, protease, inhibitors, HIV-1, proteinases, HIV-2, antiviral, inhibits, Tocris Bioscience, Other Protease Inhibitor products

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