JZP 361

Cat. No. 5851

JZP 361 C22H20ClN5O [1680193-80-9]

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Chemical Name: [4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinyl](1H-1,2,4-triazol-1-yl)methanone

Biological Activity

Potent and selective reversible MAGL inhibitor (IC50 = 46 nM). Exhibits 35-fold and 150-fold higher selectivity over human FAAH and ABHD6, respectively (IC50 values are 1.79 and 7.24 μM, respectively). Displays affinity for H1 receptors (pA2 = 6.81). Exhibits no activity at cannabinoid receptors at 10 μM.

Technical Data

Soluble to 100 mM in DMSO and to 20 mM in ethanol
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Patel et al (2015) Loratadine analogues as MAGL inhibitors. Bioorg.Med.Chem.Lett. 25 1436. PMID: 25752982.

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Keywords: JZP 361, supplier, Potent, selective, reversible, MAGL, inhibitors, inhibits, H1, histamine, receptors, Tocris Bioscience, Monoacylglycerol Lipase Inhibitor products

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