Cat. No. 5851
Chemical Name: [4-(8-Chloro-5,6-dihydro-11H-benzo[
Biological ActivityPotent and selective reversible MAGL inhibitor (IC50 = 46 nM). Exhibits 35-fold and 150-fold higher selectivity over human FAAH and ABHD6, respectively (IC50 values are 1.79 and 7.24 μM, respectively). Displays affinity for H1 receptors (pA2 = 6.81). Exhibits no activity at cannabinoid receptors at 10 μM.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Patel et al (2015) Loratadine analogues as MAGL inhibitors. Bioorg.Med.Chem.Lett. 25 1436. PMID: 25752982.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses JZP 361 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: JZP 361, supplier, Potent, selective, reversible, MAGL, inhibitors, inhibits, H1, histamine, receptors, Tocris Bioscience, Monoacylglycerol Lipase Inhibitor products
Find multiple products by catalog number
New Products in this Area
Potent and selective poly (ADP ribose) glycohydrolase (PARG) inhibitor; cell permeableURB 602
Non-competitive MAGL inhibitor(S)-Crizotinib
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.