Cat. No. 5851
Chemical Name: [4-(8-Chloro-5,6-dihydro-11H-benzo[
Biological ActivityPotent and selective reversible MAGL inhibitor (IC50 = 46 nM). Exhibits 35-fold and 150-fold higher selectivity over human FAAH and ABHD6, respectively (IC50 values are 1.79 and 7.24 μM, respectively). Displays affinity for H1 receptors (pA2 = 6.81). Exhibits no activity at cannabinoid receptors at 10 μM.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Patel et al (2015) Loratadine analogues as MAGL inhibitors. Bioorg.Med.Chem.Lett. 25 1436. PMID: 25752982.
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Keywords: JZP 361, supplier, Potent, selective, reversible, MAGL, inhibitors, inhibits, H1, histamine, receptors, Tocris Bioscience, Monoacylglycerol Lipase Inhibitor products
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