NoxA1ds

Cat. No. 5848

NoxA1ds Glu-Pro-Val-Asp-Ala-Leu-Gly-Lys-Ala-Lys-Val-NH2

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Biological Activity

Potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50 = 20 nM). Exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. Inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. Attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro. Cell permeable.

Technical Data

M.Wt:
1125.33
Formula:
C50H88N14O15
Sequence:
EPVDALGKAKV

(Modifications: Val-11 = C-terminal amide)

Solubility:
Soluble to 2 mg/ml in water
Storage:
Store at -20°C
CAS No:
1435893-78-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Ranayhossaini et al (2013) Selective recapitulation of conserved and nonconserved regions of putative NOXA1 protein activation domain confers isoform-specific inhibition of Nox1 oxidase and attenuation of endothelial cell migration. J.Biol.Chem. 288 36437. PMID: 24187133.

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Keywords: NoxA1ds, supplier, NADPH, oxidases, NOX1, inhibitors, inhibits, hypoxia, ROS, reactive, oxygen, species, Tocris Bioscience, NADPH Oxidase Inhibitor products

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