Cat. No. 5848
Biological ActivityPotent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50 = 20 nM). Exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. Inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. Attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro. Cell permeable.
(Modifications: Val-11 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Ranayhossaini et al (2013) Selective recapitulation of conserved and nonconserved regions of putative NOXA1 protein activation domain confers isoform-specific inhibition of Nox1 oxidase and attenuation of endothelial cell migration. J.Biol.Chem. 288 36437. PMID: 24187133.
If you know of a relevant reference for NoxA1ds please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses NoxA1ds from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: NoxA1ds, supplier, NADPH, oxidases, NOX1, inhibitors, inhibits, hypoxia, ROS, reactive, oxygen, species, Tocris Bioscience, NADPH Oxidase Inhibitor products
Find multiple products by catalog number
August 20 - 24, 2017
Paris , France