Cat. No. 5845
Chemical Name: Bis(morpholinothiocarbonyl) disulfide
Biological ActivityPotent and selective pyruvate dehydrogenase kinase (PDK) 1/2/3 inhibitor (IC50 values are 28, 49 and 313 nM for PDK2, PDK1 and PDK3, respectively). Exhibits selectivity for PDK1/2/3 over PDK4 and a panel of 323 other kinases. Suppresses A549 lung cancer cell proliferation in vitro. Reduces tumor volume of A549 xenografts in mice.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Sun et al (2015) JX06 selectively inhibits pyruvate dehydrogenase kinase PDK1 by a covalent cysteine modification. Cancer Res. 75 4923. PMID: 26483203.
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Keywords: JX 06, supplier, NSC402538, JX06, potent, selective, PDK1, PDK2, PDK3, pyruvate, dehydrogenase, kinases, inhibitors, inhibits, Tocris Bioscience, Other Kinase Inhibitor products
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