Cat. No. 5845
Chemical Name: Bis(morpholinothiocarbonyl) disulfide
Biological ActivityPotent and selective pyruvate dehydrogenase kinase (PDK) 1/2/3 inhibitor (IC50 values are 49, 101 and 313 nM for PDK1, PDK2 and PDK3, respectively). Exhibits selectivity for PDK1/2/3 over PDK4 and a panel of 323 other kinases. Suppresses A549 lung cancer cell proliferation in vitro. Reduces tumor volume of A549 xenografts in mice.
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Certificate of Analysis / Product Datasheet / Safety Datasheet
Sun et al (2015) JX06 selectively inhibits pyruvate dehydrogenase kinase PDK1 by a covalent cysteine modification. Cancer Res. 75 4923. PMID: 26483203.
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Keywords: JX 06, supplier, NSC402538, JX06, potent, selective, PDK1, PDK2, PDK3, pyruvate, dehydrogenase, kinases, inhibitors, inhibits, Tocris Bioscience, Other Kinase Inhibitor products
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