JZP 430

Cat. No. 5844new

JZP 430 C16H26N4O3S [1672691-74-5]

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Chemical Name: 4-(4-Morpholinyl)-1,2,5-thiadiazol-3-yl N-cyclooctyl-N-methylcarbamate

Biological Activity

Potent and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor (IC50 = 44 nM). Exhibits ~230-fold selectivity over fatty acid amide hydrolase (FAAH) and lysosomal acid lipase (LAL).

Technical Data

Soluble to 50 mM in DMSO and to 20 mM in ethanol
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Patel et al (2015) Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors. Chem.Med.Chem. 10 253. PMID: 25504894.

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