XEN 445

Cat. No. 5839

XEN 445 C18H17F3N2O3 [1515856-92-4]

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Chemical Name: 2-[(3S)-3-(2-Pyridinylmethoxy)-1-pyrrolidinyl]-5-(trifluoromethyl)benzoic acid

Biological Activity

Selective endothelial lipase (EL) inhibitor (IC50 = 237 nM for human EL). Exhibits >20-fold selectivity for EL over lipoprotein lipase (LPL) and hepatic lipase (HL). Increases high density lipoprotein cholesterol (HDLc) plasma levels in mice. Orally bioavailable.

Technical Data

M.Wt:
366.33
Formula:
C18H17F3N2O3
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
1515856-92-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Sun et al (2013) Discovery of XEN445: a potent and selective endothelial lipase inhibitor raises plasma HDL-cholesterol concentration in mice. Bioorg.Med.Chem. 21 7724. PMID: 24211162.

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Keywords: XEN 445, supplier, XEN445, Selective, endothelial, lipase, EL, inhibitors, inhibits, orally, bioavailable, Tocris Bioscience, Lipase Inhibitor products

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