Cat. No. 5838
Biological ActivityGIP receptor antagonist (IC50 = 2.6μM). Inhibits GIP-stimulated insulin release from pancreatic β cells in vitro. In ob/ob mice, blocks the effects of GIP on insulin release and plasma glucose levels. Also improves intraperitoneal glucose tolerance, insulin sensitivity, and glucose response to feeding in ob/ob mice.
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Certificate of Analysis / Product Datasheet / Safety Datasheet
Irwin et al (2007) Early administration of the glucose-dependent insulinotropic polypeptide receptor antagonist (Pro3)GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice. Diabetologia 50 1532. PMID: 17486314.
Gault et al (2002) Characterization of the cellular and metabolic effects of a novel enzyme-resistant antagonist of glucose-dependent insulinotropic polypeptide. Biochem.Biophys.Res.Commun. 290 1420. PMID: 11820780.
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Keywords: [Pro3]-GIP (Mouse), supplier, GIP, receptors, antagonists, antagonism, glucose-dependent, insulinotropic, polypeptide, diabetes, obesity, glucose, insulin, Tocris Bioscience, GIP Receptor Antagonist products