CBR 5884

Cat. No. 5836

CBR 5884 C14H12N2O4S2 [681159-27-3]

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Chemical Name: Ethyl 5-[(2-furanylcarbonyl)amino]-3-methyl-4-thiocyanato-2-thiophenecarboxylate

Biological Activity

3-Phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50 = 33 μM). Decreases de novo serine synthesis in cancer cells. Inhibits proliferation of cancer cell lines having high PHGDH expression levels.

Technical Data

M.Wt:
336.39
Formula:
C14H12N2O4S2
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
681159-27-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Mullarky et al (2016) Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers. Proc.Natl.Acad.Sci.U.S.A. 113 1778. PMID: 26831078.

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Keywords: CBR 5884, supplier, CBR5884, PHGDH, 3-phosphoglycerate, dehydrogenases, inhibitors, inhibits, serine, synthesis, cancer, Tocris Bioscience, Other Dehydrogenase Inhibitor products

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