LTURM 34

Cat. No. 5834

LTURM 34 C24H18N2O3S [1879887-96-3]

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Chemical Name: 8-(4-Dibenzothienyll)-2-(4-morpholinyl)-4H-1,3-benzoxazin-4-one

Biological Activity

Potent DNA-PK inhibitor (IC50 = 34 nM). Exhibits 170-fold selectivity for DNA-PK over PI3-K. Attenuates proliferation of a wide range of tumor cell lines in vitro.

Technical Data

M.Wt:
414.48
Formula:
C24H18N2O3S
Solubility:
Soluble to 50 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
1879887-96-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Morrison et al (2016) Synthesis, structure elucidation, DNA-PK and PI3K and anti-cancer activity of 8- and 6-aryl-substituted-1-3-benzoxazines. Eur.J.Med.Chem. 110 326. PMID: 26854431.

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Keywords: LTURM 34, supplier, LTURM34, potent, DNA-PK, inhibitors, inhibits, DAN-dependent, protein, kinases, Tocris Bioscience, DNA-Dependent Protein Kinase Inhibitor products

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