Cat. No. 5834
Chemical Name: 8-(4-Dibenzothienyll)-2-(4-morpholi
Biological ActivityPotent DNA-PK inhibitor (IC50 = 34 nM). Exhibits 170-fold selectivity for DNA-PK over PI3-K. Attenuates proliferation of a wide range of tumor cell lines in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Morrison et al (2016) Synthesis, structure elucidation, DNA-PK and PI3K and anti-cancer activity of 8- and 6-aryl-substituted-1-3-benzoxazines. Eur.J.Med.Chem. 110 326. PMID: 26854431.
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Keywords: LTURM 34, supplier, LTURM34, potent, DNA-PK, inhibitors, inhibits, DAN-dependent, protein, kinases, Tocris Bioscience, DNA-Dependent Protein Kinase Inhibitor products
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